The crosstalk between iron metabolism and immune tolerance in autoimmunity - PubMed
3 hours ago
- #immune tolerance
- #autoimmunity
- #iron metabolism
- Iron metabolism plays a critical role in immune homeostasis and autoimmunity.
- Dysregulation of iron balance contributes to oxidative stress, ferroptosis, and immune cell dysfunction.
- Iron impacts immune cell differentiation, macrophage polarization, and Treg/Th17 balance in diseases like MS, RA, and SLE.
- Iron overload in CNS (MS), synovial iron (RA), and hepcidin-driven anemia (SLE) are disease-specific mechanisms.
- Potential therapies include iron chelation, hepcidin modulation, ferroptosis inhibition, and microbiome-targeted interventions.
- Precision iron-targeted therapies and biomarkers are needed for better autoimmune disease management.