Multidomain post-stroke cognitive impairment: development and validation of a clinical prediction model - PubMed
4 days ago
- #prediction model
- #stroke
- #cognitive impairment
- Development and validation of clinical prediction models for multidomain post-stroke cognitive impairment (PSCI).
- Use of stroke-specific cognitive outcomes and predictors routinely available in electronic health records.
- Study involved 430 participants from the OCS-Recovery study, with good model performance (C-statistic 0.76).
- External validation showed similar performance (C-statistic 0.74), with best results in adults under 60 and those with moderate-to-severe acute PSCI.
- Models offer more meaningful prognoses than dementia-specific outcomes and show promise for generalizability across stroke cohorts.
- Future recalibration of domain-specific models recommended.