Impact of fitness categorization according to SIE/SIES/GITMO criteria in therapy-related and AML-MRC receiving CPX-351 - PubMed
4 hours ago
- #AML-MRC
- #fitness-criteria
- #CPX-351
- CPX-351 is the standard care for fit patients with AML-MRC and t-AML.
- Study evaluated CPX-351's cost-to-benefit ratio in AML-MRC and t-AML patients from 2019-2022.
- Patients were classified as fit or unfit using SIE/SIES/GITMO criteria based on age, comorbidities, and performance status.
- 81.4% of patients were fit, 18.6% unfit before treatment.
- Complete remission rates were similar between fit (57.3%) and unfit (56%) patients.
- Fit patients had better survival (median 18 months) compared to unfit (8 months).
- 28-day and 100-day mortality rates were lower in fit patients (4.6%, 14.3%) vs. unfit (10.7%, 32%).
- SIE/SIES/GITMO criteria effectively distinguished outcomes post CPX-351 treatment.
- Future strategies may involve updating fitness criteria to optimize CPX-351 use.