The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury - PubMed
2 hours ago
- #renal inflammation
- #NSUN7
- #SPARC
- Kidney inflammation is a major contributor to renal diseases, including acute kidney injury (AKI).
- RNA 5-methylcytosine (m5C) modifications are elevated in kidney inflammation, primarily driven by NSUN7.
- Deletion of Nsun7 in mice reduced m5C levels, attenuated inflammation, and decreased macrophage infiltration.
- SPARC was identified as a major downstream effector of NSUN7, amplifying inflammatory responses in renal cells.
- SPARC interacts with high mobility group box 1 (HMGB1) to promote proinflammatory macrophage infiltration.
- Therapeutic silencing of Nsun7 using a kidney-specific DNA tetrahedral molecular carrier alleviated inflammation and improved renal outcomes in AKI models.
- NSUN7 is a key driver of renal inflammation via SPARC regulation and a potential therapeutic target.