Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells towards glycolysis - PubMed
4 hours ago
- #mitochondrial dysfunction
- #iron overload
- #hematopoietic stem cells
- Iron overload (IO) damages mitochondria in hematopoietic stem cells (HSCs).
- IO leads to mitochondrial defects, including elevated reactive oxygen species (mtROS) and reduced oxidative phosphorylation (OXPHOS).
- HSCs under IO conditions switch to glycolysis for energy production.
- IO causes HSCs to become highly proliferative, affecting their quiescence and self-renewal.
- Restoring mitochondrial function by targeting mtROS improves HSC quiescence and self-renewal.
- The study highlights the interplay between iron, ROS, and mitochondrial activity in HSCs.