STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels - PubMed
3 hours ago
- #Alzheimer's disease
- #mitophagy regulation
- #PINK1 degradation
- The STUB1-VCP/p97 complex regulates PINK1 levels by targeting full-length PINK1 for ubiquitination and proteasomal degradation during mitophagy.
- Depletion of STUB1 stabilizes PINK1 but impairs mitophagy by accelerating parkin degradation, highlighting a delicate regulatory balance.
- In C. elegans, the STUB1-VCP axis is crucial for neuronal mitophagy and supports memory and learning capacities.
- This regulatory axis is impaired in the brains of Alzheimer's disease patients compared to healthy controls, linking it to neurodegeneration.