Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes - PubMed
4 hours ago
- #GPR183
- #monocytes
- #macrophages
- Monocytes populate tissues when local niches are depleted of tissue-resident macrophages.
- The oxysterol receptor GPR183 positions monocytes to sense niche signals that induce lung macrophage differentiation.
- Interstitial macrophages express GPR183, while alveolar macrophages do not.
- Monocyte-derived macrophages express GPR183 during differentiation.
- GPR183+ monocytes interact with fibroblasts, and lack of GPR183 causes defective lung macrophage differentiation.
- Lung fibroblasts are the source of the GPR183 ligand 7α,25-dihydroxycholesterol in the empty niche.
- Oxysterols are identified as instructive signals for tissue-resident macrophage development from monocytes.