Engineering lipid nanoparticle-stabilized emulsions for spatiotemporal mRNA delivery and enhanced T cell immunity - PubMed
3 hours ago
- #lipid nanoparticles
- #mRNA vaccine
- #T cell immunity
- Development of lipid nanoparticle-stabilized emulsions (LSE) for improved mRNA delivery and T cell immunity.
- LSE enhances antigen presentation and reduces off-target effects compared to conventional LNP systems.
- Multi-omic analyses (scRNA-seq, flow cytometry, ELISA) confirm LSE's efficacy in targeting immunocytes.
- LSE induces durable IFN-γ+ and IL-2+ T cell responses lasting up to 300 days in mice.
- Expands T cell repertoire and shows superior performance to AS01-adjuvanted Shingrix vaccine.
- Demonstrates protective and therapeutic effects against B16-OVA and LLC-NY-ESO1 tumors in mice.
- Highlights potential of spatiotemporal mRNA delivery for enhanced mRNA vaccinations.