Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy - PubMed
3 hours ago
- #chemoimmunotherapy
- #ESCC
- #metabolomics
- Longitudinal plasma metabolomics study conducted on 541 samples from 252 ESCC patients in the ESCORT-1st trial plus 288 samples from three independent cohorts.
- Developed an integrated risk assessment framework for ESCC chemoimmunotherapy: baseline predictor, on-treatment predictor, and real-time progression risk model.
- Identified dietary metabolites (S-allyl-L-cysteine from garlic and indole-3-carbinol from cruciferous vegetables) that improve outcomes by enhancing immune cell function.
- First metabolomic roadmap for precision chemoimmunotherapy in ESCC, combining prediction, surveillance, and dietary modulation.