Dissecting PGE2-driven inhibition of T cell activation using single-cell multi-omic and inflammatory bowel disease genetic association analysis - PubMed
6 hours ago
- #inflammatory bowel disease
- #T cell activation
- #PGE2
- PGE2 broadly suppresses T cell activation, but not in Th17 and T follicular helper cells.
- PGE2 significantly alters chromatin accessibility and gene expression, especially in Th17, Th1, and regulatory T cells.
- IBD-associated SNPs are enriched in open chromatin regions and linked to cell type-specific cis-regulatory elements.
- Single-cell multi-omics is used to profile T cells under various stimuli, showing its utility for defining stimulus-specific effects.