A systems biology approach to identify common molecular signatures in Hashimoto's thyroiditis and rheumatoid arthritis - PubMed
3 hours ago
- #Autoimmune Disorders
- #Bioinformatics
- #Systems Biology
- Bioinformatics analysis identified 196 differentially expressed genes (DEGs) and 10 hub genes shared between Hashimoto's thyroiditis and rheumatoid arthritis.
- Enrichment analysis linked DEGs to inflammatory and immune regulatory pathways, with activated B cells playing a central role in disease pathogenesis.
- A TF-mRNA-miRNA regulatory network pinpointed key modulators; drug target predictions highlighted CD2, CTLA4, and CD27 as potential therapeutic targets.
- Disruption of immune tolerance and aberrant immune activation are proposed as primary mechanisms driving comorbidity between these autoimmune disorders.
- Findings provide a theoretical basis for experimental validation and precision therapeutic strategy development.