PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4-Targeted Probe - PubMed
4 hours ago
- #viral myocarditis
- #PET imaging
- #DPP4 targeting
- Researchers developed a novel PET probe, 68Ga-linagliptin, targeting DPP4 for non-invasive imaging of cardiac inflammation in viral myocarditis.
- Elevated DPP4 expression in mice with CVB3-induced myocarditis was found to originate primarily from infiltrating immune cells such as T cells, dendritic cells, and B cells.
- 68Ga-linagliptin demonstrated high-affinity binding to DPP4 and significantly higher uptake in inflamed myocardium compared to controls, with PET/CT signals correlating well with histological inflammation.
- Pretreatment with unlabeled linagliptin reduced inflammation and improved cardiac function in infected mice, suggesting potential combined diagnostic and therapeutic applications.