Human Milk Oligosaccharide Synbiotic Alleviates Food Allergy in Mice by Modulating Gut Microbiota and Increasing Indole-3-lactic Acid Levels - PubMed
4 hours ago
- #food allergy
- #synbiotic
- #gut microbiota
- A novel synbiotic containing five human milk oligosaccharides (5-HMOs), Bifidobacterium bifidum R0071, bovine whey protein hydrolysate, and tryptophan was developed.
- The synbiotic demonstrated efficient production of indole-3-lactic acid (ILA) in vitro.
- In an ovalbumin (OVA)-induced food allergy mouse model, the synbiotic alleviated allergic symptoms and reduced OVA-sIgE levels.
- The treatment restored Th2/Th17 immune balance, improved intestinal barrier integrity, and activated the aryl hydrocarbon receptor.
- 16S rRNA sequencing showed enrichment of beneficial gut bacteria like Bifidobacterium, Akkermansia, and Lactobacillus johnsonii.
- Targeted metabolomics confirmed elevated intestinal ILA levels, which correlated with alleviation of food allergy.
- The study highlights the potential of targeted synbiotic interventions for modulating gut microbiota and enhancing ILA production to combat food allergies.