Single-cell analysis of recruited ILC2 cell fate during transition from circulation to establishment of tissue residency - PubMed
3 hours ago
- #ILC2
- #helminth infection
- #tissue residency
- Single-cell analysis tracks the fate of circulating group 2 innate lymphoid cells (ILC2s) during lung recruitment.
- ILC2s rapidly adopt tissue-resident gene expression upon entering the lung parenchyma from circulation.
- Converted ILC2s retain some intestinal-origin gene expression, enhancing their functionality.
- The study provides insights into ILC2 adaptation and their contribution to lung-resident populations during helminth infection.