Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction - PubMed
8 days ago
- #Adherens junctions
- #EGFR-ERK signaling
- #Mechanotransduction
- Adherens junctions enable epithelial cells to respond to mechanical stress.
- E-cadherin-containing adhesions stimulate ERK signaling in response to tissue tension.
- The mechanism involves a metalloproteinase pathway that releases EGFR ligands.
- Findings reported by Houtekamer et al. in Science Signaling.