Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities - PubMed
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- #cardiovascular disease
- #Ninjurin1
- #inflammation
- Ninjurin1 (NINJ1) is a transmembrane protein involved in plasma membrane rupture (PMR) during lytic cell death.
- NINJ1 plays dual roles: membrane-bound form promotes inflammation via DAMP release, while its soluble ectodomain (sNINJ1) has anti-inflammatory effects.
- NINJ1 is implicated in cardiovascular diseases like atherosclerosis, myocardial infarction, aortic aneurysm, and ischemia-reperfusion injury.
- Therapeutic strategies targeting NINJ1 oligomerization or using sNINJ1-mimetic peptides show promise for treating inflammatory cardiovascular diseases.