Driving CAR therapies beyond T cells - PubMed
5 hours ago
- #immune modulation
- #CAR-T therapy
- #solid tumors
- CAR-T cell therapy has transformed cancer immunotherapy for blood cancers but faces challenges in solid tumors.
- Obstacles include physical barriers, antigen diversity, and an immunosuppressive tumor environment affecting CAR-T cell effectiveness.
- Exploring CAR technology in other immune cells like macrophages, NK cells, and unconventional T cells offers new therapeutic avenues.
- These alternative CAR platforms provide unique mechanisms for tumor targeting, infiltration, and immune system modulation.
- The review discusses recent progress, compares different CAR platforms, and suggests integrating cell-specific traits with CAR design for future therapies.