Identifying Cytokine Motif-Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome - PubMed
4 hours ago
- #immunomodulation
- #colorectal cancer
- #gut microbiome
- Identified cytokine motif-containing, immunomodulatory bacterial proteins (CMCPs) in human gut microbiome.
- Found eight colorectal cancer-associated CMCPs differentially enriched in patients or healthy controls.
- Engineered E. coli Nissle 1917 (EcN) expressing CMCPs showed antitumor immune responses in Apcmin/+ mice.
- Purified CMCPs modulate mouse immune cells in vitro.
- CMCPs can serve as microbiota-derived proteins for microbiome-mediated immune therapies for colorectal cancer.