Condensin accelerates long-range intra-chromosomal interactions - PubMed
4 hours ago
- #chromosome interactions
- #3D genome organization
- #condensin
- Condensin accelerates long-range intra-chromosomal interactions in G1-arrested budding yeast.
- Chromosome motion follows the Rouse polymer model with similar diffusion parameters across loci.
- Long-range intra-chromosomal encounters occur faster than inter-chromosomal ones at similar 3D distances.
- Condensin, not cohesin, is primarily responsible for rapid intra-chromosomal interactions.
- Hi-C analysis shows condensin promotes long-distance intra-chromosomal interactions in G1 yeast.
- Polymer simulations estimate condensin extrudes chromatin at ~2 kb/s with a density of one complex per 1-2 Mb.
- Condensin's processivity is estimated at 120-220 kb.
- Findings reveal a novel role for condensin in interphase genome organization.