Mild cognitive impairment-to-Alzheimer's dementia progression risk: the contribution of the Interceptor project - PubMed
4 hours ago
- #Alzheimer's disease
- #risk prediction
- #biomarkers
- Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia, with 30-50% progressing to dementia within 3-5 years.
- The INTERCEPTOR project studied 398 individuals with MCI, using a comprehensive baseline assessment including clinical, neuropsychological, genetic, and biomarker data.
- After 3 years of follow-up, 29.6% (104 individuals) developed dementia, with 22.4% meeting Alzheimer's disease dementia criteria.
- A Cox predictive model combining clinical and sociodemographic data achieved a 72% concordance index, which increased to 82% with the addition of neuropsychological and biomarker data.
- The project developed a nomogram to predict dementia progression risk, aiming to support public health strategies like screening and treatment risk-benefit assessments.