Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators - PubMed
8 hours ago
- #drug repositioning
- #mitochondrial stress
- #lifespan extension
- Terbinafine and miglustat extend lifespan and improve healthspan in C. elegans by activating mitochondrial stress responses.
- Both compounds induce mitochondrial stress and upregulate pathways like UPRmt via ATFS-1, modulating mitochondrial function similarly to doxycycline.
- They engage the insulin/IGF-1 signaling pathway, coordinating ATFS-1 and DAF-16, revealing an integrated stress response distinct from canonical IIS activation.
- Translational potential is confirmed in human HEK293T cells, where the compounds induce mitochondrial stress and modulate function in mammalian systems.
- The study highlights mitochondrial stress response as a target for anti-aging therapies, repositioning terbinafine and miglustat for longevity and healthspan.