Aquaporin-4 suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway - PubMed
4 hours ago
- #ischemic stroke
- #neuroinflammation
- #pyroptosis
- Aquaporin-4 (AQP4) suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway.
- AQP4 deficiency worsens neurological deficits, enlarges infarct volume, and intensifies oxidative stress.
- AQP4 loss exacerbates neuronal pyroptosis, evidenced by up-regulation of NLRP1 inflammasome, increased cleaved caspase-1, and elevated gasdermin D (GSDMD).
- RNA sequencing revealed NF-κB signaling as a key downstream target of AQP4.
- AQP4 deficiency down-regulates IκBα, leading to increased NF-κB p50/p65 activity.
- AQP4 enhances IκBα expression to inhibit NF-κB signaling, dampening NLRP1 inflammasome activation and pyroptosis.
- The study highlights AQP4's role in mitigating remote secondary injury and offers insights for neuroprotective strategies.