Spastin-mediated severing of glutamylated microtubules controls cardiomyocyte coupling - PubMed
3 hours ago
- #ischemia-reperfusion
- #cardiac arrhythmias
- #microtubules
- Spastin-mediated severing of glutamylated microtubules regulates cardiomyocyte coupling, impacting cardiac electrical stability.
- Ischemia-reperfusion injury promotes accumulation of stabilized glutamylated microtubules, disrupting connexin 43 (Cx43) trafficking and leading to arrhythmias.
- Reducing microtubule glutamylation preserves Cx43 localization and mitigates injury, identifying it as a therapeutic target for ischemia-reperfusion.