The IDO1/AhR-HIF-1α metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis - PubMed
4 hours ago
- #immunometabolism
- #autoimmune-diseases
- #metabolic-reprogramming
- The IDO1/AhR-HIF-1α metabolic axis involves competition for ARNT, influencing autoimmune disease pathogenesis.
- AhR/ARNT complex promotes immune tolerance by supporting Treg cells, tolerogenic dendritic cells, M2 macrophages, and plasma cell survival.
- HIF-1α/ARNT complex enhances inflammation via glycolysis, Th17 differentiation, pro-inflammatory dendritic cells, M1 macrophages, and plasmablast proliferation.
- Autoimmune diseases (RA, SLE, MS, MN) show dysregulation with excessive HIF-1α signaling and insufficient IDO1/AhR pathway activity.
- Targeting the axis with HIF-1α inhibitors and IDO1/AhR agonists could be a novel treatment strategy for autoimmune diseases.