GLP-1 Receptor Agonists at the Crossroads of Circadian Biology, Sleep, and Metabolic Disease - PubMed
7 hours ago
- #GLP-1 receptor agonists
- #circadian rhythms
- #metabolic disease
- GLP-1 receptor agonists (GLP-1RAs) extend beyond glycemic control and weight loss, intersecting with circadian biology and sleep.
- Circadian systems regulate GLP-1 secretion, which can be disrupted by shift work, light exposure, and sleep loss.
- GLP-1 signaling influences central and peripheral circadian clock networks, suggesting a bidirectional relationship.
- Different GLP-1RAs like semaglutide and liraglutide have varied pharmacokinetics and affect sleep outcomes, including obstructive sleep apnea.
- Chronotherapy using GLP-1RAs offers personalized strategies for metabolic and sleep disorders.