S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma - PubMed
4 hours ago
- #liver metastasis
- #uveal melanoma
- #FGFR3 signaling
- S100A6 is consistently upregulated in BAP1-deficient uveal melanoma, promoting liver metastasis.
- BAP1 deficiency leads to increased H2AK119ub and Pol II recruitment at the S100A6 promoter, enhancing its transcription.
- S100A6 acts as a novel ligand for FGFR3, activating distinct signaling and inflammatory cancer-associated fibroblasts.
- Targeting the S100A6-FGFR3 pathway suppresses metastasis in preclinical models, showing therapeutic promise.