Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies - PubMed
a day ago
- #Hippo pathway
- #vascular remodeling
- #pulmonary arterial hypertension
- Pulmonary arterial hypertension (PAH) is a severe disease leading to right heart failure and high mortality.
- The Hippo signaling pathway plays a key role in PAH by affecting cell proliferation, apoptosis, and vascular remodeling.
- Disruption of the Hippo pathway, particularly involving YAP1 and TAZ, contributes to excessive cell growth and inflammation.
- The Hippo pathway interacts with other signaling axes like Notch, TGF-β, and Akt/mTOR, influencing disease progression.
- Emerging therapies targeting Hippo components, including natural products like luteolin and resveratrol, show promise for PAH treatment.
- Challenges remain due to the Hippo pathway's diverse roles and context-dependent effects.