Adverse childhood and adult experiences, intrinsic capacity decline, and subsequent physical-psychological-cognitive multimorbidity: a prospective cohort study from China - PubMed
8 hours ago
- #multimorbidity
- #aging
- #intrinsic capacity
- The study examined associations between adverse childhood/adult experiences (ACEs/AAEs), intrinsic capacity decline, and physical-psychological-cognitive multimorbidity (PPC-MM) in a Chinese cohort.
- Higher cumulative ACE exposure was significantly associated with lower intrinsic capacity (β = -0.04 per ACE), while AAEs showed no significant association with intrinsic capacity.
- Childhood physical abuse was strongly linked to reduced intrinsic capacity (β = -0.12).
- Both ACEs and AAEs independently increased PPC-MM risks: each additional ACE increased hazard by 19%, and each additional AAE by 18%.
- Individuals exposed to both ACEs and AAEs had the highest risk of physical-psychological multimorbidity (HR 1.77).
- Multistate analyses indicated multimorbidity progressively accumulated, often transitioning from physical-psychological combinations to PPC-MM.
- Findings support intrinsic capacity as an early, adversity-sensitive marker linking life-course stress to multimorbidity.