Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis - PubMed
5 days ago
- #genetics
- #lipid metabolism
- #PBDE
- Genetic variations interact with PBDE exposure to influence dyslipidemia risk.
- 3,571 genetic variants identified that interact with PBDE exposure to affect lipid homeostasis.
- Glycine and glycerophosphate are key mediators in the metabolic response to PBDE exposure.
- A polygenic risk score enhances dyslipidemia prediction in highly PBDE-exposed individuals.
- rs9869609 is a candidate causal variant strongly associated with hypercholesterolemia risk.
- Functional validation shows rs9869609-G allele downregulates SLC6A20, impairing glycine transport and promoting cholesterol accumulation.
- The study reveals a gene-environment interaction mechanism affecting lipid metabolism under PBDE exposure.