Glycolytic metabolic reprogramming and mitochondrial dysfunction: A novel mechanism underlying PAEs-promoted cartilage inflammatory phenotype - PubMed
4 hours ago
- #cartilage damage
- #mitochondrial dysfunction
- #PAEs
- Phthalate esters (PAEs) are environmental endocrine disruptors linked to various diseases, but their role in cartilage damage is unclear.
- Study explores PAEs' correlation with knee osteoarthritis (KOA) using network toxicology and molecular docking, identifying key regulatory molecules (MMP9, EGFR, IL-10, BCL2, CASP3).
- PAEs exposure activates the CASP3 pathway, inducing chondrocyte apoptosis and promoting inflammatory phenotypes.
- Proteomic analysis and cell experiments reveal PAEs trigger glycolytic metabolic reprogramming, inhibit oxidative phosphorylation, and damage mitochondrial homeostasis.
- Findings provide a theoretical basis for understanding PAEs-driven chondrocyte damage and inform therapeutic and environmental toxicity assessment strategies.