The association between prescribed hormonal contraception and multiple sclerosis risk: a systematic review and meta-analysis - PubMed
3 hours ago
- #Meta-Analysis
- #Hormonal Contraception
- #Multiple Sclerosis
- The study examines the association between hormonal contraception (HC) use and multiple sclerosis (MS) risk.
- A systematic review and meta-analysis of 11 studies (6 cohort, 5 case-control) was conducted.
- Findings were mixed: 5 studies found no significant association, 4 found decreased risk, and 2 found increased risk.
- Meta-analysis of unadjusted odds ratios (OR) showed a 1.28 increased risk of MS with HC use (95% CI 1.08-1.52).
- Adjusted ORs and sensitivity analyses showed no significant association, with high heterogeneity observed.
- Only three studies were classified as high-quality, indicating a need for further well-designed research.
- Conclusion: No statistically significant association was found, but a possible increased risk warrants more investigation.