Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan - PubMed
7 hours ago
- #lifespan
- #immune aging
- #single-cell sequencing
- Study examines single-cell transcriptional and epigenomic changes in human blood immune cells from mid-fetal to late adulthood.
- Identifies age-associated reprogramming in lymphoid and myeloid lineages, with T cells showing the most significant transcriptional changes.
- ITGB1+CD8+ effector memory T cells found to have a protective role in young adulthood.
- AREG+ natural killer (NK) cells, an immunosuppressive subset, are enriched in early childhood with low cytotoxic and high inhibitory markers.
- Fetal-derived XCL2+CD56bright NK cells show upregulation of inhibitory receptor KLRC1.
- IL1Bhi monocytes increase with aging, contributing to inflammaging.
- Provides a comprehensive single-cell atlas of peripheral immune cell dynamics across the human lifespan.
- Reveals age-related immune signatures, offering insights into immune aging and age-related diseases.