Obesity in Type 1 Diabetes: Moving Beyond the "Lean" Disease Paradigm to Understand Risk, Complications, and Treatment - PubMed
a day ago
- #Diabetes Complications
- #Type 1 Diabetes
- #Obesity
- Overweight and obesity are increasingly common in people with type 1 diabetes mellitus (T1DM).
- Obesity may increase the risk of incident T1DM and is associated with poorer glycemic control and increased risk of complications.
- Weight gain in T1DM is driven by intensive insulin therapy, hypoglycemia-related compensatory intake, activity avoidance, insulin resistance, and genetic/hormonal factors.
- Higher adiposity in T1DM is linked to increased risks of cardiovascular events, mortality, retinopathy, diabetic kidney disease, and neuropathy.
- Treatment options for obesity in T1DM include lifestyle approaches, adjunct liraglutide, semaglutide, tirzepatide, sodium-glucose cotransporter-2 inhibitors, and bariatric surgery, each with specific risks and benefits.
- Longer-term, T1DM-specific RCTs are needed to guide weight management and evaluate emerging therapies.