Platelet mTOR Is a Regulator of Sterile Immunothrombosis - PubMed
8 hours ago
- #platelet
- #mTOR
- #immunothrombosis
- Platelet mTOR regulates sterile immunothrombosis but is not essential for hemostasis in mice.
- Mice lacking platelet mTOR showed reduced platelet activation, procoagulant potential, and interactions with leukocytes.
- Platelet mTOR selectively regulates Rac1-dependent pathways affecting sustained platelet function.
- Platelet mTOR knockout mice were protected from ischemic stroke and venous thrombosis due to reduced thrombosis and inflammation.
- mTOR is a promising therapeutic target for immunothrombotic conditions with a good safety profile.