TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation - PubMed
7 hours ago
- #DNA replication
- #checkpoint signaling
- #genome stability
- TONSOKU (TSK/TONSL) pathway prevents large tandem duplications linked to replication stress.
- tsk mutants in Arabidopsis accumulate heritable duplications via DNA Polymerase δ activity.
- Duplications occur in late replicating heterochromatin, causing developmental phenotypes through ATR-WEE1 checkpoint activation.
- Suppressing ATR-WEE1 signaling reduces phenotypes, highlighting a novel source of copy number variation in eukaryotes and disease.