U2AF1 modulates alternative exon selection and guards zygotic splicing activation in mouse preimplantation embryogenesis - PubMed
4 hours ago
- #U2AF1
- #Alternative Splicing
- #Embryogenesis
- U2AF1 regulates alternative exon selection during mouse preimplantation embryogenesis.
- Polypyrimidine tract (PPT) composition and length influence splice site definition and exon inclusion/exclusion.
- U2AF1 is low in abundance and dispersed in 2-cell embryos, with overexpression causing developmental arrest and defective zygotic genome activation.
- U2AF1 promotes exon exclusion in a PPT-dependent manner and modulates U2AF dimer recognition of PPTs.
- U2AF1 hypoexpression balances gene variants like Bclaf1 and Ezh2, aiding protein isoform maintenance and embryonic development.