Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure in global cohorts - PubMed
4 hours ago
- #Clinical Trials
- #Organ Failure
- #ACLF
- Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure (ACLF).
- A-TANGO OF score introduces new thresholds for organ dysfunction and failure, including an additional ACLF grade 4.
- The score increases ACLF diagnosis from 24% to 36% and improves net reclassification index by 16%.
- Two new prognostic scores (A-TANGO ACLF-WBC and ACLF-CRP) show strong correlations with 28-day and 90-day mortality.
- Validated in large global cohorts, the A-TANGO OF score enhances risk stratification and treatment assessment.
- The score is designed for clinical trials, reducing required sample size and providing measurable endpoints like ACLF resolution.
- Addresses limitations in current EASL-CLIF criteria, improving identification of high-risk patients and short-term mortality prediction.