Co-delivery nanoparticle targeting CAF for simultaneous activating T cell plus NKT cell attack in solid tumor - PubMed
a day ago
- #Solid Tumor
- #Immunotherapy
- #Nanoparticles
- Development of FAP-α responsive nanoparticle (α-GC/NAV)-CPC targeting CAFs in solid tumors.
- Co-encapsulation of navitoclax (NAV) and alpha-galactosylceramide (α-GC) to activate NKT cells and eliminate CAFs.
- Significant reduction in tumor interstitial fluid pressure (IFP) by 4.9-fold compared to saline control.
- Increased infiltration of NKT and T cells in tumors by over 5 and 4 times respectively.
- 66.7% of mice achieved tumor eradication without recurrence in in vivo models.
- Effective prevention of lung metastatic nodules in pulmonary metastasis challenge.