An atlas of exposome-phenome associations in health and disease risk - PubMed
3 hours ago
- #phenome
- #exposome
- #health-risk
- Study conducted an exposome-wide association study with 619 exposure indicators and 305 phenotypes.
- Replicable signals were concentrated in cardiometabolic and anthropometric phenotypes.
- Triglycerides were most strongly associated with multidomain exposures like trans fatty acids and pollutants.
- Tobacco-specific biomarkers were more associated with reduced lung function than nicotine metabolites.
- Aggregate 'poly-exposomic' models explained phenotypic variation similar to genome-wide polygenic scores.
- Exposome globes revealed interconnected architecture where exposures rarely act in isolation.
- Findings highlight exposures likely to add value to disease risk assessment and population surveillance.