Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy - PubMed
4 hours ago
- #Tumor Microenvironment
- #Natural Killer Cells
- #Glioma Immunotherapy
- NK cells are innate immune cells that can kill tumor cells without prior sensitization, but their function is impaired in the glioma microenvironment.
- The glioma tumor microenvironment suppresses NK cell function through mechanisms like MHC-I overexpression, TGF-β secretion, IDO, and MDSC recruitment.
- NK cell infiltration, cytotoxicity, and ligand-receptor interactions (e.g., NKG2D, KIRs, CX3CR1+) influence glioma patient prognosis and treatment response.
- Therapeutic strategies include activating NK cells with drugs (bortezomib, decitabine), blocking inhibitory receptors (NKG2A, CD161), and combining with checkpoint inhibitors.
- CAR-NK cells targeting antigens like EGFR, HER2, GD2, and CD133 show promise in preclinical glioma models due to enhanced specificity and lower toxicity compared to CAR-T cells.