Trem1 regulates neutrophil metabolism and recruitment in lung ischemia-reperfusion injury - PubMed
3 hours ago
- #Trem1
- #Lung Transplantation
- #Neutrophil Metabolism
- Primary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) is a major complication after lung transplantation.
- Triggering receptor expressed on myeloid cells 1 (Trem1) plays a key role in neutrophil function and metabolic reprogramming during lung IRI.
- Trem1 deficiency reduces neutrophil and macrophage recruitment, NET formation, and tissue damage in a murine model.
- Multi-omics analysis shows Trem1 deletion suppresses oxidative phosphorylation (OXPHOS) and shifts neutrophil metabolism toward glycolysis.
- Clinical samples indicate TREM1+ neutrophil abundance correlates with PGD severity and OXPHOS activity.
- Targeting Trem1 may offer a novel therapeutic strategy to mitigate PGD and improve lung transplant outcomes.