Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy - PubMed
3 hours ago
- #exercise intolerance
- #breast cancer
- #cardiovascular disease
- Long-term survivors of breast cancer treated with doxorubicin and trastuzumab-based chemotherapy are at increased risk of cardiovascular disease.
- The study found that survivors exhibited sympathetic neural hyperactivity, vascular dysfunction, and exercise intolerance compared to controls.
- Survivors showed higher muscle sympathetic nerve activity, lower brachial artery flow-mediated dilation, and reduced peak oxygen uptake.
- Circulating endothelial cell-derived extracellular vesicles and reactive oxygen species bioactivity were higher in survivors.
- Twenty-eight plasma metabolites differed between survivors and controls, indicating alterations in the circulating milieu.
- No differences were observed in carotid-femoral pulse wave velocity, left ventricular ejection fraction, and global longitudinal strain.
- The findings suggest that sympathetic overdrive and vascular dysfunction may contribute to increased cardiovascular disease risk in survivors.