An arabinogalactan from Bupleurum chinense DC. attenuates LPS-induced inflammation in RAW264.7 macrophages - PubMed
4 hours ago
- #polysaccharide
- #anti-inflammatory
- #Bupleurum chinense DC.
- An arabinogalactan (BCP-WB) from Bupleurum chinense DC. was studied for its anti-inflammatory effects.
- BCP-WB has a molecular weight of 34.4 kDa and a complex structure with specific linkages.
- The study evaluated BCP-WB's effects in LPS-induced RAW264.7 cells and CuSO4-induced zebrafish, showing reduced inflammation.
- Mechanistically, BCP-WB downregulates NF-κB, TNF, and cell cycle pathways, and binds directly to TLR4.
- BCP-WB suppresses NF-κB and MAPK signaling cascades, attenuating inflammatory responses.