Pathogenic mechanisms of action of autoantibody-mediated central nervous system disorders targeting neuroglial surface antigens - PubMed
4 hours ago
- #autoantibody
- #neuroglial surface antibodies
- #central nervous system
- Autoantibody-mediated diseases target central nervous system antigens, manifesting as encephalitis or demyelination.
- Neuroglial surface antibodies (NGsAbs) target proteins like leucine-rich glioma inactivated 1, contactin-associated protein-like 2, N-methyl-D-aspartate receptor, aquaporin-4, and myelin oligodendrocyte glycoprotein.
- NGsAbs are directly pathogenic and associated diseases respond to immunotherapy.
- Pathogenic mechanisms of NGsAbs are not fully understood but involve multiple effector mechanisms.
- The review outlines clinical syndromes linked to NGsAbs and studies elucidating their pathogenic mechanisms.
- Understanding immunobiology of these conditions informs refined therapeutic approaches.