Effects of race distance and probiotics intervention on kidney, muscle, and gut injury and inflammation biomarker responses during running - PubMed
4 hours ago
- #kidney injury
- #probiotics
- #exercise physiology
- Prolonged intense physical activity like long-distance running may cause systemic inflammation and organ injury, particularly to the kidneys.
- A randomized study of 34 participants in trail races (20–164 km) assessed kidney and muscle injury and gut inflammation biomarkers, with some receiving Lactiplantibacillus plantarum 299v (Lp299v) supplementation for 4 weeks prior.
- Running increased tubular and glomerular kidney injury markers, fecal calprotectin levels, and sometimes urine myoglobin, with more pronounced effects in ultra-distance races (≥107 km).
- Lp299v supplementation showed a protective effect against gut inflammation but did not significantly influence a composite tubular kidney injury biomarker variable.
- The findings suggest ultra-distance running exacerbates kidney and muscle injury and gut inflammation, and probiotics like Lp299v may help mitigate gut inflammation, though more research is needed on mechanisms linking gut health and kidney injury during extreme exercise.