STAMBPL1 promotes the progression of gastric cancer via deubiquitinating IQGAP1 to activate the JAK2/STAT3 pathway - PubMed
6 days ago
- #Gastric Cancer
- #Deubiquitination
- #JAK2/STAT3 Pathway
- STAMBPL1 is overexpressed in gastric cancer (GC) and linked to advanced disease stages and poor prognosis.
- STAMBPL1 promotes GC progression by deubiquitinating IQGAP1, stabilizing it, and activating the JAK2/STAT3 pathway.
- Functional assays show STAMBPL1 enhances GC cell proliferation, migration, invasion, and tumor growth in vitro and in vivo.
- Pharmacological inhibition of JAK2 by AG490 reduces tumor progression, highlighting the therapeutic potential of targeting this pathway.
- The study identifies STAMBPL1 as a novel oncogenic deubiquitinase in GC, offering a new therapeutic target.