Plasma isomiRs as Candidate Biomarkers for Amyotrophic Lateral Sclerosis - PubMed
7 hours ago
- #biomarkers
- #isomiRs
- #ALS
- Plasma isomiRs are proposed as diagnostic biomarkers for Amyotrophic Lateral Sclerosis (ALS).
- TDP-43 plays a role in processing microRNAs (miRNAs) into mature products, influencing isomiR profiles.
- The study compared isomiRs and miRNAs for ALS classification, finding isomiRs more effective.
- Differential expression analysis showed more isomiRs than miRNAs were altered in ALS samples.
- An XGBoost classifier using isomiRs accurately distinguished ALS samples from controls and other diseases.
- The study suggests isomiRs could enhance noncoding RNA-based diagnostics for ALS.