Dietary Fiber Alleviates Gut Microbiota Dysbiosis Caused by High Bile Acids - PubMed
12 hours ago
- #dietary fiber
- #bile acids
- #gut microbiota
- High bile acid (BA) levels are linked to metabolic diseases like hyperlipidemia, diabetes, and obesity.
- BAs influence glucose, lipid, and energy metabolism, with gut microbiota playing a key role in BA metabolism.
- An in-vitro colonic simulation system was used to study the effects of dietary fiber on gut microbiota under high BA conditions.
- High BA levels reduced microbial diversity, increased opportunistic pathogens, and inhibited beneficial bacteria like Bifidobacterium.
- Different dietary fibers (arabinose, galactooligosaccharide, mannooligosaccharide, resistant dextrin, stachyose) showed type- and dose-dependent effects on microbiota.
- A composite dietary fiber formula (ZH) increased propionic acid, reduced pathogens, and enriched beneficial bacteria like Limosilactobacillus.
- The study provides insights into using dietary fiber to mitigate BA-induced gut microbiota dysbiosis.