Genetic and environmental mediators of multiple sclerosis susceptibility but not early severity run in families - PubMed
4 days ago
- #Vitamin D
- #Genetic Risk
- #Multiple Sclerosis
- Multiple sclerosis (MS) susceptibility and severity are influenced by different genetic and environmental factors.
- Familial aggregation in MS is partially explained by susceptibility determinants, but its impact on early disease course after clinically isolated syndrome (CIS) is uncertain.
- The study included CIS participants within six months of symptom onset, assessing family history, genetic risk scores (wGRS), vitamin D levels, BMI, and HLA-DRB1*15:01 carriership.
- Results showed familial MS was associated with higher MS susceptibility wGRS and more frequent HLA-DRB1*15:01 carriership, but not with differences in anti-EBNA1 IgG or 25(OH)D levels.
- Participants with first-degree MS relatives had genetic risk scores for lower vitamin D and higher adult BMI.
- Baseline characteristics and disease severity measures were similar between participants with and without familial MS.
- The study concludes that familial MS is linked to genetic risk for MS susceptibility, low vitamin D, and high BMI, but not with early disease course after CIS.