CALR/HIF-1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT-Mediated Bladder Cancer Progression via ROS/AKT Axis - PubMed
8 hours ago
- #HIF-1α
- #bladder cancer
- #CALR
- CALR expression is significantly elevated in bladder cancer (BLCA) and linked to poor prognosis.
- A positive feedback loop between CALR and HIF-1α drives CALR upregulation in BLCA.
- CALR stabilizes HIF-1α, while HIF-1α transcriptionally increases CALR expression.
- CALR promotes EMT-mediated tumor progression via ROS accumulation and AKT pathway activation.
- Sinapine is identified as a direct inhibitor of CALR, suppressing BLCA growth in vitro and in vivo.
- The study provides a foundation for CALR as a prognostic biomarker and therapeutic target in BLCA.